RAF Typhoon FGR4s have operated alongside French warplanes in a joint strike against an subterranean weapons facility in Syrian territory used by the IS group, according to the British defence ministry.
The location, located using surveillance, was thought to be housing weapons and explosive materials, the release indicated, and was positioned in mountainous terrain just to the north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized laser-guided Paveway IV weapons to strike a series of access tunnels providing entry to the depot... initial indications indicate the strike was effective," the MoD said.
There was no sign of any harm to civilians in the operation late on Saturday and each participating jet returned to base without incident, the ministry further stated.
The Typhoon fighters were assisted by a Voyager tanker plane.
Daesh - referred to as Daesh - established extremist governance over parts of Syria and Iraq prior to its 2019 collapse.
"This strike underscores our UK leadership, and resolve to stand shoulder to shoulder with our allies, to stamp out any resurgence of Daesh and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief John Healey stated.
British military aircraft have conducted surveillance missions over Syria to "prevent any attempted resurgence" of the group after its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I must thank all the members of the UK armed forces involved in this strike for their expertise and their bravery," he said. "They were part of numerous British personnel stationed over the festive period. This mission, to remove terrorist threats who pose a risk to our safety, demonstrates how our armed forces are prepared to act, throughout the year, keeping Britain secure at home and influential overseas."
During December, the US military carried out what it termed a "massive strike" targeting IS targets in the country, following an assault killed two US servicemembers and a local interpreter in the Palmyra area.
The U.N. reports Daesh still has an estimated 5,000 to 7,000 militants in Iraq and Syria.